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2 144 676

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Application

96113747/14, 1996-07-08

(24)

Start date

1996-07-08

(22)

Actual filing date

1996-07-08

(45)

Published

2000-01-20

(72)

Inventor

Kozlov L.V.D'Jakov V.L.Batalova T.N.Guzova V.A.Lysakova S.V.

(73)

Holder

Moskovskij Nauchno-Issledovatel'Skij Institut Ehpidemiologii I Mikrobiologii Im.G.N.Gabrichevskogo

METHOD OF ASSAY OF FUNCTIONAL ACTIVITY OF HUMAN C1Q SUBCOMPONENT OF COMPLEMENT Russian patent published in 2000 - IPC

Abstract RU 2144676 C1

FIELD: medicine, medicinal immunology. SUBSTANCE: invention relates to methods of assay of functional activity of complement components in human serum blood in diagnosis of some diseases and in biological preparations. Micropanel is sensibilized with nonspecific human or animal immunoglobulins G and M. Then solution containing subcomponent C1q, conjugate of immunoglobulins with enzyme and substrate for this enzyme are added into micropanel wells successively and C1q is determined quantitatively by the enzymatic reaction end product. In part, conjugate with nonspecific human or animal immunoglobulins G and M is used as conjugate of immunoglobulins with enzyme, namely the conjugate with immunoglobulins - antibodies raised to C1q. Method ensures to determine functional activity of the first component of complement system based on immunoenzyme analysis. EFFECT: simplified method, decreased cost. 3 cl, 3 ex

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RU 2 144 676 C1

Authors

Kozlov L.V.

D'Jakov V.L.

Batalova T.N.

Guzova V.A.

Lysakova S.V.

Dates

2000-01-20—Published

1996-07-08—Filed

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