FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel biologically active compounds, method of patient treatment with their using and pharmaceutical composition based on compounds said. 1-N-Alkyl- -N-arylpyrimidineamines correspond to the general formula (I) 
where radical values are given in the invention claim. Proposed pharmaceutical composition containing compounds of the general formula (I) taken in the effective amount has additionally a carrier and shows activity on CRF-receptors. Method of treatment of patients with diseases caused by activity of CRF-receptors in effective disorders, anxiety state and others involves administration of active compounds of the formula (I) in therapeutically effective dose in mammals. EFFECT: new compounds indicated above, valuable pharmacological properties. 10 cl, 22 tbl, 105 ex
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