PHOSPHINIC ACID AMIDES AND METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENTS ASSOCIATED WITH UNFAVORABLE METALLOPROTEASE ACTIVITY Russian patent published in 2001 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to phosphinic acid amides of the formula (I) where R₁ means hydrogen atom, alkyl, phenylalkyl, indolyl, phenylalkoxyalkyl, R₂ alkylthioalkyl, alkylaminoalkyl; R₃ means alkyl or phenyl; R₄ means alkyl, phenyl or substituted phenyl, pyridyl, thienyl or furyl and to their optical isomers, diastereomers, enantiomers, pharmaceutically acceptable salts or biohydrolyzed esters that can be used as inhibitors of matrix metalloprotease in treatment of patients with states with excessively elevated activity of indicated enzymes. EFFECT: valuable medicinal properties of compounds. 10 cl, 2 tbl, 21 ex