FIELD: veterinary science. SUBSTANCE: invention relates to agents of specific prophylaxis of plague, infectious hepatitis and parvoviral enteritis in dogs. Vaccine has the novel attenuated strain "VNIIVViM-88" of carnivore plague virus with infectious activity 3.5-4.5 lg TPD 50/cm3. Strain is cultured in subline CV-1 of African green monkey kidney cells. Vaccine has also vaccine strain "Kornell-2" of canine infectious hepatitis virus with infectious activity 5.5-6.5 lg TPD 50/cm3. Strain is cultured in piglet testicle cells transplanted culture. Also, vaccine has vaccine strain "A" of feline panleukopenia virus with infectious activity 3.5-4.5 lg TPD 50/cm3 and hemagglutinating activity in RGA = (1:32)-(1:512). Strain is cultured in kitten kidney cells transplanted culture (subline Fk). Vaccine has also drying medium based on lactose, sucrose, sorbitol and gelatin. Vaccine shows harmlessness, areactivity, high antigenic and immune activity, stability in storage, standard traits and high technological effectiveness of preparing. EFFECT: improved quality and properties of vaccine. 2 tbl, 3 ex
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Authors
Dates
2000-08-20—Published
1997-12-04—Filed