METHOD FOR PREDICTING HEMORRHAGE COMPLICATIONS DEVELOPMENT IN LABOR BASED ON HEMOSTASIS SYSTEM DATA AT THE SECOND HALF OF PREGNANCY TERMS Russian patent published in 2000 - IPC

Abstract RU 2156469 C1

FIELD: medicine. SUBSTANCE: method involves studying pregnant women hemostasis system at the second and the third trimester of gestation period within the framework of monitoring research. Thrombin time and fibrinogen concentration are used as significant information signs of hemostasiogram during the second trimester. Pattern recognition techniques are applied for determining F value assumed by function defined by a formula F=0.96A- 0.024B-2.51, where A is the fibrinogen concentration in g/l, B is the thrombin time in s. The value of F being greater than 0.31, postpartum hemorrhage is predicted. The value of F being less than -0.27, pathologic blood losses are predicted during the labor. Fibrinogen concentration β in plasma and the level of D dimers, blood platelets number and thromboelastogram parameter K obtained under conditions of high contact activation of hemocoagulation, are used as significant information indices of hemostasiogram during the third trimester. Pattern recognition techniques are applied for determining P value of function defined by a formula P=-0.89C-0.59D-0.014E+0.012G-1.14, where C is the fibrinogen β concentration in plasma in g/l, D is the level of D dimers in ng/ml, E is the blood platelets number 109/ml, G is the K parameter in mm. The value of P being greater than 0.2, postpartum hemorrhage is predicted. The value of P being less than -0.2, pathologic blood losses are predicted during the labor. The value of F being within the limits of -0.27 to 0.31 and P being within the limits of -0.2 to 0.2, uncertain prognosis zone is considered to be the case. EFFECT: enhanced reliability in selecting hemorrhage complications development risk groups.

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RU 2 156 469 C1

Authors

Medvinskij I.D.

Jakubovich O.I.

Zislin B.D.

Jurchenko L.N.

Mazurov A.D.

Cherdantseva G.A.

Dates

2000-09-20Published

1999-04-02Filed