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Application

99105823/14, 1999-03-16

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Start date

1999-03-16

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Actual filing date

1999-03-16

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Published

2000-10-10

(72)

Inventor

Alekseev V.V.Vjaz'Mina T.N.Plekhanova N.G.Demedjuk E.A.Popov S.F.Kapliev V.I.Piven' N.N.

(73)

Holder

Volgogradskij Nauchno-Issledovatel'Skij Protivochumnyj Institut

METHOD FOR MODELING PULMONARY MELIOIDOSIS Russian patent published in 2000 - IPC

Abstract RU 2157538 C1

FIELD: medicine. SUBSTANCE: method involves using white rats as experimental animals. The animals are infected with suction doses equal to 1.3-20 LD50 (LD50=3133 cells) of P. Pseudomallei strain 100-16-1 deprived of antigen-8 as one of virulence factors. Infecting is carried out in dynamic aerosol installation of 0.29 m diameter at 0.15-0.5 m/s air flow rate. Aerosol generator performance is 30 l/min with air and 1.5-3.0 l/min with liquid. Infection time is 5 min. EFFECT: reproducible form of acute melioidosis with benign transformation in 50% of cases. 4 dwg, 1 tbl

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RU 2 157 538 C1

Authors

Alekseev V.V.

Vjaz'Mina T.N.

Plekhanova N.G.

Demedjuk E.A.

Popov S.F.

Kapliev V.I.

Piven' N.N.

Dates

2000-10-10—Published

1999-03-16—Filed

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