FIELD: medical and pharmaceutical industries. SUBSTANCE: described are new substituted 6R-1,3,4-thiadiazine-2-amines of formula I: 
wherein Ar is phenyl or phenyl substituted by one or more chlorine, bromine, C1-C4 alkoxy or C1-C4 alkyl groups; each of R1 and R2 is independently hydrogen atom or C1-C4 alkyl residual; and R3 and R4 are independently selected from C1-C4 alkyl groups, and pharmaceutically acceptable salts thereof. Said compounds are useful as anesthetizing, cardiovascular and hypometabolic agents. Also described are pharmaceutical compositions which comprise said agents. EFFECT: improved properties of the pharmaceutical composition. 7 cl, 10 ex, 2 tbl
| Title |
Year |
Author |
Number |
| SUBSTITUTED 6H-1,3,4-THIADIAZINE-2-AMINES, THEIR USE AS ANESTHETIC, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF |
1995 |
- Chupakhin O.N.(Ru)
- Sidorova L.P.(Ru)
- Tarakhtij Eh.A.(Ru)
- Novikova A.P.(Ru)
- Perova N.M.(Ru)
- Vinogradov V.A.(Ru)
- Mishel' Frantsiskus Van Ginkel'
|
RU2157210C2 |
| SUBSTITUTED 5R,6R -1,3,4-THIADIAZINE-2-AMINES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AS PHARMACOLOGICALLY ACTIVE AGENTS ELICITING ANTICOAGULANT AND ANTI-AGGREGATING EFFECT |
2003 |
- Chupakhin O.N.
- Sidorova L.P.
- Perova N.M.
- Charushin V.N.
- Rusinov V.L.
- Muljar A.G.
|
RU2259371C2 |
| PHARMACEUTICALLY ACCEPTABLE SALTS OF SUBSTITUTED 6H-1,3,4- -THIADIAZINE-2-AMINES AND THEIR PHARMACEUTICAL COMPOSITIONS |
1995 |
- Chupakhin O.N.(Ru)
- Sidorova L.P.(Ru)
- Tarakhtij Eh.A.(Ru)
- Novikova A.P.(Ru)
- Perova N.M.(Ru)
- Vinogradov V.A.(Ru)
- Mishel' Frantsiskus Van Ginkel'
|
RU2152943C1 |
| DERIVATIVES OF DIHYDROBENZOPYRANE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS OF TREATMENT |
1997 |
- Janush Dzhon Majkl
- Dzhonson Karl Randol'F
- Senanajake Chandravansha Bandara V.
|
RU2156762C1 |
| DERIVATIVES OF 3-HYDROXY-2-PYRIDONE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2003 |
- Varshakun Namal Chizranga
- Bush Rodni Dian
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RU2311410C2 |
| HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND APPLICATION METHOD THEREOF |
2007 |
- Grehj Dzheffri Lajl
- Amarasinge Kande
- Klark Sintija Moneza
- Majer Meht'Ju Brajan
- Nikols Rajan
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RU2430101C2 |
| PHOSPHINIC ACID AMIDES AND METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENTS ASSOCIATED WITH UNFAVORABLE METALLOPROTEASE ACTIVITY |
1997 |
- Pikul Stanislav
- Makdau-Dankhehm Kelli Linn
- De Bisvanatkh
- Tajvo Ietunde Olabisi
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RU2170232C2 |
| HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND APPLICATION METHODS THEREOF |
2007 |
- Grehj Dzheffri Lajl
- Amarasige Kande
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- Majer Meht'Ju Brajan
- Nikols Rajan
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| DERIVATIVES OF QUINOLONE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1998 |
- Ledussal' Benua
- Almstid Dzi-In Kim
- Grej Dzheffri Lajl
- Khu Ksiufeng Ehrik
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RU2193558C2 |
| DERIVATIVES OF 5-HYDRAZINOQUINOLONE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF INFECTION DISEASE, METHOD OF TREATMENT AND PROPHYLAXIS |
1993 |
- Demut Tomas Prosser
- Uajt Ronal'D Judzhin
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RU2126000C1 |
