FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to biologically active compounds, in particular, to substituted 5R1,6R2-thiadiazine-2-amines and pharmaceutical compositions comprising thereof that can be used in medicine as potential pharmacologically active substances eliciting the unique combination of properties: expressed anticoagulant activity in combination with capacity to inhibit aggregation of platelets. Effect of these substances differ from preparations used in medicinal practice and they can be used therefore in treatment of such diseases as myocardium infarction, disturbance in cerebral circulation, rejection of transplanted organs and tissues and so on. Indicated compounds correspond to the formula (I):
wherein values of radicals R1, R2 and R3 are given in the invention claim.
EFFECT: valuable medicinal properties of compounds.
4 cl, 2 tbl, 7 dwg, 33 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 6H-1,3,4-THIADIAZINE-2-AMINES, THEIR USE AS ANESTHETIC, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF | 1995 |
|
RU2157210C2 |
| SUBSTITUTED 6R-1,3,4-THIADIAZINE-2-AMINES AND PHARMACEUTICAL COMPOSITION THEREOF | 1995 |
|
RU2157808C2 |
| PHARMACEUTICALLY ACCEPTABLE SALTS OF SUBSTITUTED 6H-1,3,4- -THIADIAZINE-2-AMINES AND THEIR PHARMACEUTICAL COMPOSITIONS | 1995 |
|
RU2152943C1 |
| 5-(4'-HYDROXYPHENYL)-AND 5-(2',5'-DIHYDROXYPHENYL)-6 H-1,3,4-THIADIAZINE-2-AMINES, HYDROHALOGENIDES INHIBITING THROMBOCYTE AGGREGATION IN INTRAVENOUS INTRODUCTION | 2009 |
|
RU2458060C2 |
| 2-AMINOPROPYLMORPHOLINO-5-ARYL-6H-1,3,4-THIADIAZINES, DIHYDROBROMIDES AND 2-AMINOPROPYLMORPHOLINO-4-ARYLTHIAZOLES, HYDROBROMIDES SHOWING ANTIAGGREGANT ACTION | 2011 |
|
RU2456284C1 |
| 2-CYCLOALKYLAMINO-5-THIENYL-1,3,4-THIADIAZINES, HYDROBROMIDES, WITH ANTIAGGREGANT ACTIVITY | 2008 |
|
RU2379306C1 |
| 2-CYCLOALKYLIMINO-5-(4-NITROPHENYL)-1,3,4-THIADIAZINES POSSESSING BIOLOGICAL ACTIVITY AGAINST SMALLPOX VIRUS | 2005 |
|
RU2281946C1 |
| 2-PIPERIDINO-5-(THIENYL-2)- AND 2-PIPERIDINO-5-(THIENYL-3)- 6H-1,3,4-THIADIAZINES HYDROBROMIDES POSSESSING ANTIAGGREGANT ACTION | 2010 |
|
RU2445310C2 |
| [1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES EXHIBITING ACTIVITY AGAINST INFLUENZA VIRUS, AND METHOD FOR PRODUCTION THEREOF | 2022 |
|
RU2824814C2 |
| PYRROLO[2,1-f][1,2,4]TRIAZINE COMPOUND, METHOD FOR PRODUCTION AND USE THEREOF | 2013 |
|
RU2589053C1 |
