METHOD OF DIRECTION OF IMMUNE RESPONSE INDUCTION, DNA, VECTOR, METHOD OF TREATMENT Russian patent published in 2000 - IPC

FIELD: biotechnology, medicine, immunology. SUBSTANCE: mammal is subjected to administration of transformed immune cells that express chimeric receptor containing an extracellular component that is able to recognize infectious agent and an intercellular component originating from polypeptide CD3 or η T-cellular receptor, or polypeptide of B-cellular receptor, or polypeptide of Fc-receptor that has ability to transfer destructive signal to the cell. Inclusion of an extracellular component CD4 recognizing and binding HIV and an intercellular component originating from polypeptide CD3 or η T-cellular receptor to chimeric receptor provides to transfer to the cell signal for destruction of HIV or HIV-infected cell. EFFECT: improved method of direction and treatment. 32 cl, 45 dwg, 11 ex