FIELD: organic chemistry, biochemistry, medicine, pharmacy. SUBSTANCE: invention describes the novel derivatives of amidinosulfones of the formula (I) 
where R1 is methyl or fluoromethyl group or their salt, ester or amide. Compounds are able to selective inhibition of activity of NO-synthase isozyme that produces nitrogen oxide. Compounds can be used for treatment of patients with septic shock or shock induced by sudden hepatic insufficiency. Invention describes also methods of synthesis of compounds of the formula (I), pharmaceutical composition and treatment method. EFFECT: improved method of inhibition and treatment. 9 cl
| Title |
Year |
Author |
Number |
| AMIDINE DERIVATIVES |
1992 |
- Richard Mehnsfild Bims
- Garol'D Frehnsis Khodson
- Richard Majkl Dzhon Pehlmer
|
RU2130014C1 |
| 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD LIPID LEVEL, METHOD OF TREATMENT OF MAMMAL CLINICAL STATE, METHOD OF SYNTHESIS OF COMPOUND |
1995 |
|
RU2156245C2 |
| SUBSTITUTED CARBOCYCLIC AMIDES, METHODS OF PREPARATION THEREOF, INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS OF PROPHYLAXIS OR MEDICAL TREATMENT |
1995 |
- Masso Dejvid Li
- Kelli Dzhejmz Leroj
|
RU2145954C1 |
| DERIVATIVES OF 5,6-DICHLOROBENZIMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS |
1995 |
- Chejmberlejn Stehnli Doz
- Koszalka Dzhordzh Uolter
|
RU2145963C1 |
| CHLOROPYRIMIDINE INTERMEDIATE COMPOUNDS |
1995 |
- Dehjljudzh Sjuzen Mehri
- Martin Majkl Tolar
- F'Judzhett Mishell' Dzhoann Ferri
|
RU2140913C1 |
| METHOD OF SYNTHESIS OF LAMOTRIGINE AND INTERMEDIATE COMPOUND USED FOR ITS SYNTHESIS |
1995 |
|
RU2162081C2 |
| METHOD OF LAMOTRIGINE PRODUCING, INTERMEDIATE COMPOUNDS AND METHOD OF PHARMACEUTICAL COMPOSITION PREPARING |
1995 |
- Uinter Rejmond Dzheffri
- Sojer Dejvid Alan
- Dzhermejn Ehndr'Ju
|
RU2145602C1 |
| 4-AMINO-2-(4-METHYLPIPERAZINE-1-YL)-5-(2,3,5-TRICHLOROPHENYL)- -PYRIMIDINE AND ITS SALTS OF ACID ADDITION, METHODS OF THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1989 |
- Miller Ehlistehjr Ehjnsli
- Nobbz Mal'Kol'M Stjuart
- Gajd Richard Martin
- Lich Majkl Dzhon
|
RU2171256C2 |
| 4-[2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURINE-9-YL]-2-CYCLOPENTENE- -1-METHANOL SUCCINATE AS ANTIVIRAL AGENT |
1995 |
- Dehjljudzh S'Juzen Meri
- Uilson Dzheffri Daglas
|
RU2145324C1 |
| PYRIMIDINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION |
1989 |
- Ehlistehjr Ehjnsli Miller
- Mal'Kol'M Stjuart Nobbz
- Richard Martin Gajd
- Majkl Dzhon Lich
|
RU2121998C1 |
