FIELD: biochemistry. SUBSTANCE: oligonucleotides are modified for hindering or at least essentially inhibiting their degradation with nucleases occurring in nature. Oligonucleotide radical is specifically bound with high binding affinity to target structures and produces in this manner specific therapeutic and diagnostic action by means of bound complex-generating agent or complex. EFFECT: wider number of preparation for diagnosing pathologic states. 17 cl, 3 dwg
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