FIELD: chemistry.
SUBSTANCE: invention discloses versions of a method of preparing a mixture which contains an activated polymer which has a multifunctional binding group, where the activated polymer is polyalkylene oxide. The obtained mixture is suitable for subsequent conjugation with biologically active molecules.
EFFECT: efficient production of polymer conjugates such as branched PEG-polypeptide conjugates on an industrial scale without purification of activated PEG linkers through column chromatography in order to remove impurities.
35 cl, 3 dwg, 2 tbl, 7 ex
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