DERIVATIVES OF 1,3,4-OXADIAZOLONE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of 1,3,4-oxadiazolone of the formula (I) where A means linear linkage or -CH₂O-; B means linear linkage or oxygen atom; D means -(CH₂)_n- or -CH₂CHOHCH₂-; n is whole number from 1 to 4; R means -NR¹R² or -NR¹R²R³X where X is an anti-ion; each of R¹, R², R³ means independently hydrogen atom or C_1-4-alkyl. Invention relates also to their pharmaceutically acceptable salts or solvates. Invention provides also pharmaceutical composition and method of treatment or protection against disturbances mediated by opening potassium channels activated by calcium. 1,3,4-Oxadiazole-2(3H)-ones are useful for treatment of disorders in humans arising as result of polarization dysfunction and cellular membrane conductivity and their application is preferable for treatment of ischemia and hemorrhage. EFFECT: improved and valuable medicinal properties of compounds. 16 cl, 17 ex