DERIVATIVES OF BUTADIENE AND METHOD OF THEIR SYNTHESIS, DERIVATIVES OF AMIDOBUTADIENE AND METHOD OF THEIR SYNTHESIS, DERIVATIVES OF PYRROLIDINE AND METHOD OF THEIR SYNTHESIS Russian patent published in 2001 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel derivatives of butadiene of the formula (I-a) where A means pyridine, pyrimidine or benzene ring that can be substituted optionally; B means pyridine, oxo-substituted pyridine, pyrimidine, benzene or C_1-4-alkylenedihydroxy-substituted benzene ring; R¹ means C_1-6-alkyl; R² means hydrogen atom; -COR³² means C_2-7-alkoxy-carbonyl and so on; -COR⁴² means carboxyl group and so on, or its pharmaceutically acceptable salts; derivatives of amidobutadiene of the formula (I-b) where values A, B, R¹,R²,-COR³² are given above; -COR⁴³ means carbamoyl group that can be substituted optionally and so on, or its pharmaceutically acceptable salts; derivative of pyrrolidine of the formula (2) where A, B, R¹,R² are given above; R⁵ means pyridyl-substituted C_1-6/ -alkyl group and so on, or its pharmaceutically acceptable salt. Method of synthesis of compound of the formula (I-a) involves treatment of diester compound of the formula (4) with acid or base followed by conversion of product to its pharmaceutically acceptable salt. Method of synthesis of compound of the formula (I-b) involves interaction of compound of the formula (I-a) with compound of the formula (5) H-R⁴⁰ (5) where R⁴⁰ means free or substituted amino-group. Method of synthesis of compound of the formula (2) involves reaction of intramolecular cyclization of compound of the formula (I-c) . EFFECT: new compounds, improved method of synthesis. 15 cl, 43 tbl, 184 ex