FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of indoline-2-one of the formula (I) 
where W means the group -CH2- or SO2; Cy in common with carbon atom to which it is bound form nonaromatic saturated hydrocarbon cycle with 3-6 carbon atoms; T means alkylene with 1-4 carbon atoms or a simple bond; Z means amino-group; R1,R2,R3 and R4 are hydrogen atom or substituents, for example, halogen atom, alkyl and so on. New derivatives show affinity for receptors of vasopressin and/or oxytocin and can be used as active components of pharmaceutical compositions. Invention describes also method of their synthesis and pharmaceutical compositions containing thereof. EFFECT: new compounds indicated above, valuable pharmacological properties. 17 cl, 2 tbl, 54 ex
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Year |
Author |
Number |
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1993 |
- Lois Fulon
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- Dino Nizato
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- Zherar Valett
- Zhan Van'On
|
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1994 |
- Alen Di Mal'Ta
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- Daniel' Mettefe
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- Rishar Ru
- Klodin Serradej-Legal'
|
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2005 |
- Abuabdella Akhmed
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- Marge Frank
|
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1996 |
- Daniell' Gjulli
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- Kamil' Zhorzh Vermut
|
RU2146253C1 |
| ARYLOXYALKYLCARBAMATE DERIVATIVES, SYNTHESIS THEREOF AND USE IN THERAPY |
2005 |
- Abuabdella Akhmed
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- Fruassan Zhak
- Khornart Kristian
|
RU2392269C2 |
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1996 |
- Bart Fransis
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- Rinal'Di Mjuriel'
- Sarran Martin
|
RU2170230C2 |
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1995 |
- Daniel' Bishon
- Patrik Gele
- Did'E Van Broskk
- Ksav'E Ehmond-Al'T
- Vensanzo Pruaetto
|
RU2143425C1 |
| HETEROARYLALKYLCARBAMATE DERIVATIVES, THEIR OBTAINING AND THEIR APPLICATION AS ENZYME FAAH INHIBITORS |
2005 |
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- Rave Antuan
|
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2004 |
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- Labev Bernar
|
RU2348630C2 |
| INDOLINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION |
1992 |
- Zhan Van'On[Fr]
- Klod Pluzan[Fr]
- Klodin Serradej-Legal'[Fr]
- Dino Nizato[It]
- Bernar Tonner[Fr]
|
RU2104268C1 |
