DERIVATIVES OF NEURAMINIC ACID, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT AND PROPHYLAXIS OF INFLUENZA Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of neuraminic acid of the general formula (I) where R¹ means methyl group; R², R³ and R⁴ can be similar or distinct and each means hydrogen atom or aliphatic acyl group containing 3-25 carbon atoms; W means hydrogen atom or ester residue under condition that compounds of the formula (I) where each of R², R³ and R⁴ and W means hydrogen atom are excluded. Derivatives of neuraminic acid of the present invention show high inhibitory effect with respect to sialidase in vivo and they are useful as therapeutic agents or agents for prophylaxis of viral influenza infection. Invention describes also pharmaceutical composition and method of treatment and prophylaxis of influenza. EFFECT: new compounds indicated above, valuable medicinal properties. 33 cl, 4 tbl, 11 ex