CRYSTALLINE DEOXYSPERGUALINE TRIHYDROCHLORIDE IN β-FORM ELICITING ANTITUMOR ACTIVITY AND METHOD OF ITS PREPARING Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to crystalline deoxyspergualine trihydrochloride in β-form of the formula: β- exhibiting the following parameters of roentgen-ray diffraction in powder-like state: : 15.77; 10.91; 4.88; 4.67 : 0.32; 0.42; 0.39; 0.53 I/I_I: 4.14; 3.66; 3.31; 3.21 : 0.70; 1.00; 0.52; 0.52 that shows antitumor activity and to method of its preparing. Method of preparing involves crystallization of powder or syrup-like aqueous suspension of deoxyspergualine trihydro-chloride from an aqueous ethanol at the concentration of water 15 vol. %, not above. EFFECT: improved method of preparing, valuable antitumor properties. 2 cl, 5 tbl, 2 dwg