DERIVATIVES OF SUCCINOYLAMINOHYDROXYETHYLAMINOSULFONEAMIDE, A PHARMACEUTICAL COMPOSITION, A METHOD OF INHIBITION OF RETROVIRAL PROTEASE, A METHOD OF TREATMENT OF PATIENTS WITH RETROVIRAL INFECTION, A METHOD OF TREATMENT OF PATIENTS WITH HIV-INFECTION Russian patent published in 1999 - IPC

Abstract RU 2130016 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of succinoylaminohydroxyethylamino-sulfoneamide of the formula (I) where R1 - H, C1-C10-alkyl; R2 is C1-C10-alkyl, aryl-C1-C10-alkyl possibly substituted with halogen atom or C3-C8-cycloalkyl; R3 is C1-C10-alkyl, C1-C10-halogen-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C10-alkyl; R4 is C1-C10-alkyl, C1-C10-halogenalkyl, C3-C8-cycloalkyl, phenyl possibly substituted with one or some substituents taken from amino-group, halogen atom, C1-C10-alkyl, C1-C10-alkoxy-group, C1-C10-halogenalkyl or hydroxy-group; X1 - oxygen, nitrogen atom; R31,R32 - H, C1-C10-alkyl; R33,R34 independently - H, phenyl-C1-C10-alkyl at condition that if X1 means oxygen atom then R34 is absent; t = 0, 1. Compounds are used as a pharmaceutical composition showing antiviral activity for treatment of patients with retroviral infection. EFFECT: antiviral activity of compounds, improved method of treatment. 36 cl, 9 tbl, 10 ex

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RU 2 130 016 C1

Authors

Majkl L.Vaskuz

Richard Mjuller

Dzhon Dzh.Tehlli

Daniel Getman

Gehri A.Dekrechentso

Dzhon N.Freskos

Dates

1999-05-10Published

1993-08-25Filed