METHOD FOR EVALUATING PERTUSSIS VACCINE TOXICITY Russian patent published in 2001 - IPC

Abstract RU 2174229 C2

FIELD: medicine. SUBSTANCE: method involves carrying out intraperitoneal immunization of mice with pertussis vaccines pretreated with high frequency ultrasonic radiation of 42-50 kHz during 5 min at a dose of 1.5 billions of MB in volume of 0.5 ml. The mice are decapitated 7 days later. Ultrastructural slices of the brain are examined under electronic microscope. Myelin fiber demyelination shaped as braids being observed, toxic action of the vaccine under test on the nerve system is concluded to be the case. EFFECT: simplified method; accelerated treatment course. 1 tbl

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RU 2 174 229 C2

Authors

Moskalenko E.P.

Il'Ina S.I.

Urazovskij S.F.

Dates

2001-09-27Published

1999-08-06Filed