METHOD OF PREPARING PERTUSSOID ANTIGEN COMPLEX Russian patent published in 1995 - IPC

Abstract SU 1767975 A1

FIELD: medicine. SUBSTANCE: method involves cultivation of pertussoid bacteria on medium KUA, preparing of suspension of pertussoid bacteria, its disintegration by low-frequency ultrasonic, centrifugation. Then detoxifying solution containing formaldehyde 0.033 M is added to prepared antigen complex, shook at the room temperature for 20-25 min and incubated at 45 C for two days. Method ensures to decrease toxic properties of parent antigen complex and retain high immunogenicity. EFFECT: decreased toxicity of antigen complex

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SU 1 767 975 A1

Authors

Moskalenko E.P.

Poverennyj A.M.

Kharseeva G.G.

Il'Ina S.I.

Dates

1995-04-10—Published

1990-11-06—Filed