FIELD: public health, microbiology, vaccine prophylaxis.
SUBSTANCE: invention can be used for evaluation of immunogenic properties of anti-whooping vaccines making for series producing. Method provides reducing time for analysis, consumption of testing vaccines and elimination of laboratory animals. Testing anti-whooping vaccine is treated with low-frequency ultrasonic oscillation 42-50 kHz for 5 min and the neutralization reaction of antigen with erythrocytes sensitized with whooping toxin and hyperimmune serum against whooping toxin is carried out followed by determination of amount whooping toxin. Testing vaccine is defined as highly immune in the value of whooping toxin from 18 ± 1.45 mcg/ml and above.
EFFECT: improved evaluating method.
3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR EVALUATING PERTUSSIS VACCINE TOXICITY | 1999 |
|
RU2174229C2 |
| METHOD FOR EVALUATING WOOPING COUGH VACCINE TOXICITY | 2001 |
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RU2227293C2 |
| METHOD OF PROTECTIVE WHOOPING COUGH ANTIGEN PREPARING | 1999 |
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| METHOD FOR MODELING SECONDARY IMMUNODEFICIENCY STATE OF T- CELL TYPE | 1992 |
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| METHOD OF PREPARING PERTUSSOID ANTIGEN COMPLEX | 1990 |
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| ASSESSMENT METHOD FOR PROTECTIVE POTENCY OF PERTUSSIS VACCINES | 2015 |
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RU2623314C2 |
| METHOD OF IMMUNIZATION WITH BACTERIAL PREPARATIONS CONTAINING ENDOTOXIN | 0 |
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SU1306582A1 |
| METHODS FOR ASSESSING THE PROTECTIVE ACTIVITY AND IMMUNOGENICITY OF PERTUSSIS VACCINES IN HUMANS, THE USE OF LIVE PERTUSSIS RECOMBINANT VACCINE GamFA | 2021 |
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RU2799018C2 |
| METHOD OF EVALUATION OF VACCINE WHOOPING COUGH PREPARATION TOXICITY | 1994 |
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RU2092844C1 |
| ATTENUATED BACTERIA BORDETELLA PERTUSSIS, WHOOPING COUGH AGENT VACCINE | 2010 |
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