NOVEL IMMUNOTHERAPEUTIC COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD OF DECREASE OF LEVELS OF PHDE, TNF ALPHA AND NFKB Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel immunotherapeutic compounds of the formula: α where X means O- or where n has value 0, 1, 2 or 3; -(C_nH_2n)- means alkyl containing from 1 to 10 carbon atoms or monocycloalkyl containing up to 10 carbon atoms; R¹ means hydrogen atom, lower alkyl or lower alkoxy-group; R² means: (1) unsubstituted phenyl or naphthalene or phenyl or naphthalene substituted with one or more substitutes being each is taken independently among nitro-group, halogen atom, amino-group, amino-group substituted with alkyl containing 1-5 carbon atoms, alkyl containing up to 10 carbon atoms, cycloalkyl containing up to 10 carbon atoms, alkoxy-group containing up to 10 carbon atoms, cycloalkoxy-group containing up to 10 carbon atoms, phenyl or methylenedioxy-group; (2) pyridine; each of R³ and R⁴ taken separately means hydrogen atom; or R⁵ and R⁴ taken in common mean a bond carbon-carbon; Y means COZ, R⁵ or lower alkyl containing from 1 to 5 carbon atoms; Z means OH, -C≡N or NR⁶R⁶, -R⁷; -OR⁷ means hydrogen atom or lower alkyl; and R⁶ means alkyl. These compounds are inhibitors of tumor necrosis R⁷-factor, nuclear factor kB and phosphodiesterase and can be used for control of cachexia, endotoxic shock, replication of retroviruses, asthma and inflammatory states. Invention relates to also a pharmaceutical composition based on these compounds and a method of decrease of levels of PHDE (phosphodiesterase), tumor necrosis α-factor (TNFα) and nuclear factor kB (NFkB). EFFECT: new immunotherapeutic compounds indicated above, valuable medicinal properties. 9 cl, 1 tbl