SUBSTITUTED AMIDES, METHOD OF DECREASE OF TUMOR NECROSIS FACTOR (TNF) LEVEL AND INHIBITION OF PHOSPHODIESTERASE ACTIVITY AND PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention describes novel substituted imides of the general formula (I) where Y means or ; m = 0-3; R⁵ means: unsubstituted o-phenylene or o-phenylene substituted with one or more substitutes each of that is taken independently from nitro-group, C_1-4-alkyl, amine, carbamoyl substituted with C_1-3-alkyl, acetoxy-, carboxy-, hydroxy-, amino-group substituted with C_1-3-alkyl or bivalent residue of pyridine, pyrrolidine, imidazole, naphthalene or thiophene; R⁶ means -CO-, -CH₂-, -CH₂CO-, SO₂; R⁷ means phenyl substituted with two substitutes taken independently among unbranched or cyclic C₁-C₁₀-alkoxy-group; n = 0, 1, 2 or 3. Invention relates also to method of decrease of levels of tumor necrosis α-factor, method of inhibition of activity of phosphodiesterase and to pharmaceutical composition. These compounds are inhibitors of tumor necrosis α-factor and phosphodiesterase and can be used for control against cachexia, endotoxic shock, replication of retroviruses, asthma and inflammatory states. EFFECT: improved method of decrease of tumor necrosis factor levels and inhibition of phosphodiesterase activity. 5 cl