METHOD OF SYNTHESIS OF INDOLE DERIVATIVE Russian patent published in 2001 - IPC

Abstract RU 2176243 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of indole derivatives of the general formula (I) that are semiproducts and can be used for synthesis of pyrroloindoles and mitomycins where R1 and R2 mean OCH3; R means Ph (Ia) or R means tert.-Br-Ph (Ib) or R means CH3 (Ic); or R1 and R2 mean H; R means Ph (Id) or R means p-CH3 (Ie) or R means p-Br-Ph (If) or R means p-Cl-Ph (Ig). Method of synthesis involves heating derivatives of 2-tosylaminoarylfurylmethane of the formula (2) in saturated solution of gaseous hydrogen chloride in ethanol at 70-78 C for 10-30 min. Method provides to synthesize compounds with yield 70-75% and to decrease resinification. EFFECT: improved method of synthesis, increased yield, enhanced quality of products. 2 tbl, 4 ex

Similar patents RU2176243C2

Title Year Author Number
METHOD FOR PREPARING 2,4-DIALKYLINDOLO[2,3-H]-1-OXAAZULENIUM CHLORIDES 2003
  • Smirnov S.K.
  • Butin A.V.
  • Stroganova T.A.
RU2243971C1
METHOD FOR PREPARING 4-[1-(TOLYL-4-SULFONYL)-1H-INDOLYL-2]-BUT-3-ENE-2-ONE'S 2005
  • Smirnov Sergej Konstantinovich
  • Butin Aleksandr Valerianovich
RU2294325C2
METHOD OF OBTAINING DERIVATIVES OF N-ACETYL-4-HYDROXY-2METHYL-5-(5-METHYLFUR-2-YL)-1H-BENZO[g]INDOLE 2008
  • Butin Aleksandr Valerianovich
  • Abaev Vladimir Tajmurazovich
  • Mel'Chin Vladimir Viktorovich
  • Pilipenko Arkadij Sergeevich
  • Fin'Ko Aleksandr Valer'Evich
RU2368611C9
METHOD OF PRODUCING INDOLIZINO[7,6-b]INDOLE DERIVATIVES 2010
  • Pilipenko Arkadij Sergeevich
  • Uchuskin Maksim Grigor'Evich
  • Butin Aleksandr Valerianovich
  • Trushkov Igor' Vladimirovich
RU2439073C1
METHOD OF OBTAINING DERIVATIVES OF 8H-THIENO[2,3-b]INDOLE 2007
  • Butin Aleksandr Valerianovich
  • Tsiunchik Fatima Alekseevna
  • Abaev Vladimir Tajmurazovich
RU2345082C1
METHOD OF PRODUCING 11H-INDOLO[2,3-c]QUINOLINE DERIVATIVES 2010
  • Pilipenko Arkadij Sergeevich
  • Uchuskin Maksim Grigor'Evich
  • Butin Aleksandr Valerianovich
RU2439071C1
METHOD OF PREPARING 2,5-DIALKOXY-2,5-DIHYDROFURANS 1997
  • Poskonin V.V.
  • Badovskaja L.A.
  • Povarova L.V.
RU2124508C1
AZAINDOLE-INDOLE DERIVATIVES, METHODS FOR PREPARING AND USING 2008
  • Cheng Tszjansaj
  • Jao Kizheng
  • Uong Zhaokhuj
  • Khua Vehji
RU2486184C2
METHOD OF PRODUCING (E)-4-(6,7-DIMETHOXY-2-METHYL-3-QUINOLYL)-3-BUTEN-2-ONE DERIVATIVES 2010
  • Kostjukova Ol'Ga Nikolaevna
  • Tsiunchik Fatima Alekseevna
  • Lysenko Sergej Aleksandrovich
  • Trushkov Igor' Viktorovich
  • Butin Aleksandr Valerianovich
RU2425034C1
SYNTHESIS OF 3-(5-METHYLFUR-2-YL)BENZOFURANE DERIVATIVES POSSESSING HYPOTENSIVE, ANTIANGINAL, AND ANTIARYTHMIC ACTIVITIES 1997
  • Kadieva M.G.
  • Oganesjan Eh.T.
  • Abaev V.T.
  • Butin A.V.
  • Gutnov A.V.
  • Ivashev M.N.
RU2138492C1

RU 2 176 243 C2

Authors

Butin A.V.

Stroganova T.A.

Lodina I.V.

Krapivin G.D.

Dates

2001-11-27Published

2000-02-23Filed