FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a method for preparing new 2,4-dialkylindolo[2,3-h]-1-oxaazulenium chlorides of the general formula (I):
wherein Ia: R is -OCH3; R1 is CH3; Ib: R is hydrogen atom (H); R1 is CH3; Ic: R is -O-CH2-O-; R1 is CH3; Id: R is -O-CH2-CH2-O-; R1 is CH3; Ie: R is -OCH3; R1 is C2H5; If: -O-CH2-O-; R1 is C2H5. Method involves passing gaseous hydrogen chloride through solution of the corresponding 2-acetylaminoarylbis-(5-alkylfur-2-yl)methane of the formula (II):
in methanol at boiling for 80-90 min. Method provides preparing new tetracyclic derivatives eliciting the potential anticancer activity.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
2 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF INDOLE DERIVATIVE | 2000 |
|
RU2176243C2 |
| METHOD FOR PREPARING 4-[1-(TOLYL-4-SULFONYL)-1H-INDOLYL-2]-BUT-3-ENE-2-ONE'S | 2005 |
|
RU2294325C2 |
| METHOD FOR PREPARING 1,11-DIALKYL-3,5-DIHYDROFURO-[2',3':3,4]-CYCLOHEPTA[C]ISOCHROMENS | 2005 |
|
RU2282633C9 |
| SUBSTITUTED 1-PHENYL-3-CARBOXAMIDES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING AFFINITY TO HUMAN NEUROTENSIN RECEPTORS | 1996 |
|
RU2195455C2 |
| NITRATE SALTS OF HYPOTENSIVE MEDICINAL AGENTS | 1999 |
|
RU2235097C2 |
| METHOD OF OBTAINING DERIVATIVES OF N-ACETYL-4-HYDROXY-2METHYL-5-(5-METHYLFUR-2-YL)-1H-BENZO[g]INDOLE | 2008 |
|
RU2368611C9 |
| NAPHTHALENE DERIVATIVES | 2001 |
|
RU2354646C2 |
| SPIROIMIDAZOLIDINE DERIVATIVES, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2245879C2 |
| COLORED POLYSILOXANE-POLYCARBONATES AND METHOD FOR THEIR PREPARING | 2005 |
|
RU2278127C1 |
| ACRIDINE DERIVATIVES, METHOD OF SYNTHESIS, PHARMACEUTICAL COMPOSITION AND A METHOD OF TREATMENT OF PATIENTS WITH MALIGNANT TUMORS | 1992 |
|
RU2119482C1 |
