METHOD OF PRODUCING 11H-INDOLO[2,3-c]QUINOLINE DERIVATIVES Russian patent published in 2012 - IPC C07D471/04 

Abstract RU 2439071 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to novel synthesis of 11H-indolo[2,3-c]quinoline derivatives of formula I, which can be used in synthesis of novel preparations for pharmaceutical purposes. In the method of producing 11H-indolo[2,3-c]quinoline derivatives of general formula I

index R R1 R2 Н Н Н Ib Cl Н Н Ic Cl ОСН3 ОСН3 Id СН3 Н Н Ie Н ОСН3 Н

, the corresponding 4-[2-(2-nitrophenyl)-1H-indol-3-yl]-but-3-en-2-ones II are boiled in acetic acid in the presence of twenty-fold molar excess of carbonyl iron for 5 minutes.

EFFECT: method widens the range of obtained products and simplifies the process owing to use of other initial compounds and conditions.

1 cl, 4 ex, 2 tbl

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RU 2 439 071 C1

Authors

Pilipenko Arkadij Sergeevich

Uchuskin Maksim Grigor'Evich

Butin Aleksandr Valerianovich

Dates

2012-01-10Published

2010-07-05Filed