METHOD FOR PREPARING 4-[1-(TOLYL-4-SULFONYL)-1H-INDOLYL-2]-BUT-3-ENE-2-ONE'S Russian patent published in 2007 - IPC C07D209/12 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of novel compounds of formulas (Ia-g): wherein: (a) R means -OCH₃; R1 means phenyl (Ph); (b) R means -OCH₃; R1 means 4-bromophenyl (4-Br-Ph); (c) R means -OCH₃; R1 means CH₃; (d) R means -OCH₃; R1 means 4-CH₃-Ph; (e) R means -OCH₃; R1 means C₂H₅; (f) R means -OCH₃; R1 means hydrogen atom (H); (g) R means -O-CH₂-CH₂-O-; R1 means CH₃. Method involves interaction of benzhydrol of formulas (IIa-g): wherein values R and R1 are given above with N-furan-2-yl-methyl-4-methylbenzenesulfonamide of the formula: in acetic acid medium in boiling for 0.2-20 h in the presence of phosphoric acid as a catalyst wherein 3 ml of phosphoric acid are added per 0.01 mole of benzhydrol of formulas (IIa-g). Compounds of formulas (Ia-g) can be used in synthesis of novel analogs of anti-tumor preparations.

EFFECT: improved method of synthesis, valuable medicinal property of preparations.

2 tbl, 5 ex