METHOD OF PRODUCING (E)-4-(6,7-DIMETHOXY-2-METHYL-3-QUINOLYL)-3-BUTEN-2-ONE DERIVATIVES Russian patent published in 2011 - IPC C07D215/14 C07D403/12 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing (E)-4-(6,7-dimethoxy-2-methyl-3-quinolyl)-3-buten-2-one derivatives of formula I, where Ia: R¹ and R² - CH₃; Ib: R¹ - CH₃, R² - C₆H₅; Ic: R¹ - CH₃, R² - o-NO₂C₆H₄; Id: R¹ - t-Bu, R² - C₆H₅; Ie: R¹ - t-Bu, R² - p-OCH₃C₆H₄; If: R¹ - p-BrC₆H₄, R² - Ph; Ig: R¹ -CH₃, R² - thiophene; Ih: R¹ - t-Bu, R² - CH₂CH₂Ph; Ii: R¹ - t-Bu, R² - CH₂CH₂Cl; Ij: R¹ - p-BrC₆H₄, characterised by that ortho-aminoacylbenzylfuran derivatives of formula II are boiled in benzene in the presence of phosphorus oxychloride with a reflux condenser for 1.5-3.5 hours depending on substitutes R¹ and R².

EFFECT: obtaining (E)-4-(6,7-dimethoxy-2-methyl-3-quinolyl)-3-buten-2-one derivatives, pitavastatin analogues, and introduction of the required substitute into the desired compound with simultaneous formation of a quinoline nucleus.

2 tbl, 6 ex