METHOD OF SYNTHESIS OF TOLTERODINE AND INTERMEDIATE COMPOUND Russian patent published in 2001 - IPC

Abstract RU 2176246 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of tolterodine of the formula (I) and 3,4-dihydro-6-methyl-4-phenyl-2H-benzo-pyrane-2-ol of the formula (IV) as a novel intermediate compound. Method involves reduction reaction of lactone of the formula (III) to yield hydroxy-compound of the formula (IV) followed by reductive amination of the latter with diisopropylamine. (R)-tolterodine L-tartrate is useful as a drug for treatment of patients with enuresis. EFFECT: improved method of synthesis, simplified method, valuable medicinal property. 6 cl

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RU 2 176 246 C2

Authors

Gejdzh Dzhejms R.

Kabadzh Dzhon E.

Dates

2001-11-27—Published

1997-12-18—Filed