METHOD OF SYNTHESIS OF 5-HYDROXYMETHYL-SUBSTITUTED OXAZOLIDINONES, METHOD OF SYNTHESIS OF 5-AMINOMETHYL-SUBSTITUTED OXAZOLIDINONE AMINES, OXAZOLIDINONE SULFONATE Russian patent published in 2001 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 5-hydroxymethyl-substituted oxazolidinones of the formula (III) from carbamates of the formula (IIa) R₁-NH-COOM₂ (IIa) or trifluoroacetamide of the formula (IIb) R₁-NH-CO-CF₃ (IIb) using dihydroxy-compound of the formula (I) M₁-CH₂-CH(OH)-CH₂-OH (I) or glycidol as the parent substance. Invention relates to also a method of synthesis of 5-aminomethyl-substituted oxazolidinone amines of the formula (VII) by interaction of 5-hydroxy-methyl-substituted oxazolidinones of the formula (III) with sulfonating agent and the following interaction of synthesized oxazolidinone sulfonate of the formulas (VIa),(VIb) , (VIc) , (VId) with ammonia under pressure less than 207 kPa (2.1 ati). Invention relates to also new derivatives of oxazolidinone sulfonate of the formula (VIa - VIb) where R₁ means (a) ; X¹ means H or F; X¹² means H or F; Q¹ means (b) ; Z² means -N(R⁷)-, -O-; R⁷ means R³-O-C(O)- where R³ is phenyl; m = 1; n₁ = 0, 1 or 2; n₂ = 0, 1 or 2; n₃ = 5-(n₁ + n₂). EFFECT: new method of synthesis of 5-hydroxy- -methyl-substituted oxazolidinones, 5-aminomethyl-substituted oxazolidinone amines, new derivatives of oxazolidinone sulfonate. 18 cl, 4 dwg, 24 ex