BIS(AMIDES) OF NITROGEN-CONTAINING TRICYCLIC CARBOXYLIC ACIDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel bis(amides) of nitrogen-containing tricyclic carboxylic acids of the formula (I) where each X can be similar or different in this molecule and means - CH= or -N=; each of R₁- R₄ can be similar or different and means H, C₁- C₄-alkyl, NH₂, C₁- C₄-alkoxy-group, phenyl, phenoxy-group, NHR, N(R)₂,CF₃ or halogen atom where R means C₁- C₄-alkyl; each of R₅ and R₆ means H or C₁- C₄- alkyl; Z means ; R₇ is H or C₁- C₄-alkyl; n and m mean the whole number from 1 to 4, or their pharmaceutically acceptable salts with exception of compounds where each X means N, each of R₁- R₆ means H, carboxamide moiety is bound at position 1 of phenazine ring and Z means or (CH₂)₃NH(CH₂)₂NH(CH₂)₃.. Compounds of the formula (I) show antitumor activity and can be used in medicine. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 7 cl, 1 dwg, 2 tbl, 81 ex