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2 238 943

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IPC

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Application

2000133319/04, 1999-05-28

(24)

Start date

1999-05-28

(22)

Actual filing date

1999-05-28

(45)

Published

2004-10-27

(72)

Inventor

Kuk K. EhdgarKepler Dzhon A.Bartli Gari S.Shetti Rupa S.

(73)

Holder

Riserch Trajehngl Instit'Jut

HORMONAL OR ANTI-HORMONAL STEROID COMPOUNDS, METHODS FOR THERAPEUTIC EFFECT, METHOD FOR PREPARING COMPOUNDS Russian patent published in 2004 - IPC

Abstract RU 2238943 C2

FIELD: organic chemistry, steroids, medicine.

SUBSTANCE: invention relates to new steroid of the general formula (I)

that elicit as effective antagonists of progestins and mixed or incomplete agonists of progestin wherein R1 means (R2R3N(O)r)- wherein r = 0,1; each among R2 and R3 means independently hydrogen atom (H), (C1-C6)-alkyl; or R1 means

wherein q = 0, 1; Y means (CH2)m- wherein m = 1, 2, 3, 4, 5; or R1 means (C1-C6)-alkyl-CO-; R12 means hydrogen atom (H); X means oxygen atom (O) or

wherein -(CH2)m- wherein m = 2; R6 means hydrogen atom (H), (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl possibly substituted with OH or OCHO; S = 0, 1; each among R8 and R9 represents independently hydrogen atom (H), OH, (C1-C6)-alkyl, R10CO wherein R10' means hydrogen atom (H), (C1-C6)-alkyl. Compounds of the formula (I) are useful for treatment of fibromas, endometriosis, in hormone-substitution therapy and for regulation of fertility.

EFFECT: improved preparing and therapeutic effect methods.

16 cl, 4 tbl, 16 ex

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RU 2 238 943 C2

Authors

Kuk K. Ehdgar

Kepler Dzhon A.

Bartli Gari S.

Shetti Rupa S.

Dates

2004-10-27—Published

1999-05-28—Filed

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