FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a novel and thermodynamically more stable form of crystalline (R)-(-)-N-[4-dioxido-3-oxo-2,3- -dihydrobenzisothiazol-2-yl] aminomethyl] -chroman hydrochloride. The proposed hydrochloride is characterized by physical-chemical parameters given in the invention claim. It is not subjected any conversion being even at high air humidity (relative humidity is 85%, room temperature). On this base the proposed hydrochloride is especially useful for solid pharmaceutical compositions showing HT!A--agonistic activity used for treatment and prophylaxis, for example, insult. EFFECT: improved properties of substance. 7 cl, 6 dwg, 6 ex
| Title |
Year |
Author |
Number |
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1993 |
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|
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1999 |
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- Uve Petersen[De]
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|
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RU2125054C1 |
