DERIVATIVE OF 11-(PHENYL-SUBSTITUTED)-ESTRA-4,9-DIENE, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention relates to a new derivative of 11-(phenyl-substituted)-estra-4,9-diene of the formula (I) where A means a residue of 5- or 6-membered ring containing two heteroatoms which are not bound each with other and taken independently from O and S; indicated ring can be substituted with one or more halogen atoms; or residue of 5- or 6-membered ring where double bond C=C is absent has one heteroatom taken from O and S and heteroatom is bound with phenyl group at position noted by asterisk and ring can be substituted with one or more halogen atoms; R₁ means hydrogen atom; R₂ means hydrogen atom, (C_1-8)-alkyl, halogen atom or CF₃; X means O or NOH; and dotted line means a possible bond. Compounds show antiglucocorticoid activity and can be used for treatment and prophylaxis of glucocortcoid-dependent diseases. Invention describes also a method of synthesis of the above indicated compounds and a pharmaceutical composition based on compounds of the formula (I). EFFECT: improved method of synthesis, valuable pharmacological properties. 9 cl, 1 tbl, 13 ex