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2 182 494

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Application

2001114971/13, 2001-05-31

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Start date

2001-05-31

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Actual filing date

2001-05-31

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Published

2002-05-20

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Inventor

Gusev A.A.Mishchenko V.A.Sukharev O.I.Gunenkov V.V.Lisitsyn V.V.Aleksanjan R.L.

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Vserossijskij Nauchno-Issledovatel'Skij Institut Zashchity Zhivotnykh

CATTLE VIRAL PARAGRIPPE-3 STRAIN TO MANUFACTURE DIAGNOSTIC AND VACCINE PREPARATIONS Russian patent published in 2002 - IPC

Abstract RU 2182494 C1

FIELD: virology, biotechnology. SUBSTANCE: "VGNKI-4" DEP strain of cattle paragrippe-3 (PG-3) virus is obtained due to adaptation of epizootic strain to interwoven cellular culture of calf's kidneys "Taurus-1". The strain is depoted in the Collection of microorganisms under registration name of "VGNKI-4" DEP. The latter differs from both manufactured and earlier isolated epizootic strains of cattle PG-3 virus. Virus of "VGNKI-4" strain proliferates well in cellular cultures PEK, PT, MDVK, VNK-21, PC and accumulates in titers 5.0-7.51 g TCD . "VGNKI- 4" strain is stable and safe. It keeps initial characteristics at subsequent passivating in sensitive biological systems for 9-10 passages (investigation period). EFFECT: broadened antigenic range of action, higher biological and immunogenic activity, higher efficiency to be used in manufacturing efficient diagnostic and vaccine preparations. 10 ex

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RU 2 182 494 C1

Authors

Gusev A.A.

Mishchenko V.A.

Sukharev O.I.

Gunenkov V.V.

Lisitsyn V.V.

Aleksanjan R.L.

Dates

2002-05-20—Published

2001-05-31—Filed

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