ORGANIC NITRATES AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY INHIBITING PLATELET AGGREGATION BASED ON THEREOF Russian patent published in 2002 - IPC

Abstract RU 2190594 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes nitrates of the general formula: A- or their salts where t0 = 1; A means RN0 where N0 means (COXu)t or COON1 where t is a whole number equal to 0 or 1; u is a whole number equal to 0 or 1; X means O, NR1c where R1c means alkyl with a linear or branched chain having from 1 to 10 carbon atoms; N1 means alkyl with a linear or branched chain having from 1 to 10 carbon atoms or hydrogen atom; R is taken among the following groups: * (Group A) (1a): where RIa and RIIa are similar or different and mean H or linear or when is possible branched alkyl having 1-3 C-atoms, preferably, RIa = RIIa = H; nIa is a whole number from 1 to 6, preferably, from 2 to 4; RI can mean where N2 has the same value as N0 being at least one of groups N0 and N2 has one a free valence that is able to bind with X1, (i.e. t = 1); (Group B) where t = 1 and u = 0. IIa): where RIa, RIIa have values indicated for (1a); RIb has a value RIa; nIa/ has values indicated for (1a); RBA is taken among: , where in the group (B) N2 has said values and at least one of N2 groups has a free valence that is able to bind with X1 (i. e. at least one substitute N2 has t = 1); X1 means bivalent binding bridge taken among: -Y0 where Y means C1-C20-alkylene with a linear chain where possible with a branched chain having preferably from 2 to 5 carbon atoms; -Y1 taken among: where n3 is a whole number from 0 to 3. Invention describes also a pharmaceutical composition showing activity inhibiting platelet aggregation. EFFECT: synthesis of new compounds with useful biological properties, excellent safety as compared with standard compounds. 9 cl, 5 tbl, 9 ex

Similar patents RU2190594C2

Title Year Author Number
NITRATE SALTS OF HYPOTENSIVE MEDICINAL AGENTS 1999
  • Del Soldato P'Ero
RU2235097C2
NITROGEN OXIDE DONORS ABLE TO DECREASE TOXICITY OF MEDICINAL PREPARATIONS 1997
  • Del Soldato P'Ero
RU2192247C2
NITROESTERS OF CORTICOID COMPOUNDS 1997
  • Del Soldato P'Ero
RU2186781C2
NITROOXYDERIVATIVES OF FLUVASTATIN, PRAVASTATIN, CERIVASTATIN, ATOVASTATIN AND ROSUVASTATIN AS CHOLESTEROL-REDUCING AGENTS WITH IMPROVED ANTI-INFLAMMATORY, ANTITHROMBOTIC, ANTI-THROMBOCYTIC ACTIVITY 2004
  • Benedini Francheska
  • Ongini Ehnnio
  • Del' Soldato P'Ero
RU2362770C2
NEW MEDICINAL AGENTS 2000
  • Del Soldato P'Ero
RU2237057C2
STEROIDS THAT RELEASE NITROGEN OXIDE 2008
  • Benedini Francheska
  • Biondi Stefano
  • Ongini Ehnnio
RU2442790C2
NITROXYCOMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING ANTI-INFLAMMATORY, ANALGETIC AND ANTITHROMBOCYTIC ACTIVITY 1995
  • Del Soldato P'Erro
  • Sannikolo Franchesko
RU2145595C1
NEW MEDICINAL AGENTS 2000
  • Del Soldato P'Ero
RU2237657C2
NITROOXYDERIVATIVE STEROIDS 2006
  • Benedini Francheska
  • Ongini Ehnnio
  • Guglietta Antonio
  • Palop Daniel'
  • Prinsep Marta
RU2415864C2
NITROCOMPOUNDS AND PHARMACEUTICAL COMPOSITION SHOWING ANTI-INFLAMMATORY AND ANTITHROMBOTIC ACTIVITY 1996
  • Del Soldato P'Ero
  • Sannikolo Franchesko
RU2165921C2

RU 2 190 594 C2

Authors

Del' Soldato P'Ero

Dates

2002-10-10Published

1997-11-12Filed