C-MET/HGFR INHIBITOR POLYMORPHS Russian patent published in 2010 - IPC C07D401/04 A61K31/4155 A61P35/00 

Abstract RU 2387650 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a free base (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)- ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine in crystalline form, having a powder X-ray diffraction pattern with peaks at diffraction angles (2θ) 15.7±0.1, 17.3±0.1 and 19.7±0.1. The invention also relates to a pharmaceutical composition, to methods of treating cancer in mammals, as well as to a method of treating abnormal cell growth in mammals in need of such treatment.

EFFECT: obtaining an novel biologically active compound having the said inhibitory activity.

12 cl, 1 ex, 3 tbl, 2 dwg

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RU 2 387 650 C2

Authors

Kui Dzhingrong Dzhin

Trehn-D'Jub Mishel' Bich

Dates

2010-04-27Published

2006-11-23Filed