FIELD: organic chemistry and technology. SUBSTANCE: product: amino-substituted benzoylguanidines of the formula (I)* where: and R1 - R2; NR3R4 and R3 - H, R4-alkyl or C1-C6 - phenyl-R3; p = 0-4; or (CH2)p and R3 together form R4-methylene chain where C4-C7-group can be substituted with NH; CH2 or R1 - H, F, Cl, R2-alkyl, C1-C4-alkoxy or phenoxy. Reagent 1: C1-C4. Reagent 2: guanidine HN= . Synthesized compounds were used in medicine since they show antiarrhythmic properties. EFFECT: improved method of synthesis. 20 ex, 4 cl
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Authors
Dates
1997-07-27—Published
1993-02-12—Filed