BENZOYLGUANIDINES, METHOD OF PREPARATION THEREOF, INTERMEDIATES FOR THEIR PREPARATION, INHIBITION METHOD, AND DRUG Russian patent published in 2000 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: benzoylguanidines of formula 1: (1), wherein one of three substituents R(1), R(2), and R(3) is C_aH_2a-(C₁-C₉)-heteroaryl-N-oxide optionally substituted by 1-3 substituents selected from trifluoromethyl and methyl, a=1, 2 or 3, and other substituents from R(1), R(2), R(3), independently from each other, are hydrogen, group (CH₂)_p-(C_qF_2q+1), or group R(22)-SO_u, perfluoroalkyl moiety in next to last group having linear or branched chain, u=0, 1 or 2, q is integer from 1 to 6, R(22) is C1-C8-alkyl, trifluoromethyl or C_rF_2r+1, r is integer from 1 to 4, or their pharmaceutically acceptable salts. Compounds 1 show excellent effect on blood circulation system. EFFECT: extended assortment of cardio-vascular preparations. 16 cl, 3 ex