N-SUBSTITUTED DERIVATIVES OF ANILINE SHOWING INHIBITORY EFFECT ON NO-SYNTHASE ACTIVITY, THERAPEUTIC AGENT BASED ON THEREOF, DERIVATIVES OF NITROPHENYLCARBOXYLIC ACID Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes derivatives of aniline of the formula (I) where R₁ means SR₆ or NR_YR₈; R₆ means direct or branched alkyl group and others; R₇ means hydrogen atom, direct or branched alkyl group and others; R₈ means hydrogen atom, direct or branched alkyl group; R₂ means hydrogen atom, direct or branched group and others; R₃ means hydrogen atom or direct or branched alkyl group and others; R₄ means hydrogen atom, direct or branched alkyl group and others; R₅ means hydrogen atom, direct or branched alkyl group and others; Y₁,Y₂,Y₃,Y₄ mean hydrogen, halogen atom, hydroxy-group and others; n and m each = 0 or 1, or possible stereoisomers or optically active forms of compounds or their pharmaceutically acceptable salts. Compounds show strong inhibitory effect on activity of NO-synthase and they are used as therapeutic agents for treatment of patients with cerebrovascular diseases, for example, cerebral hemorrhage, cerebral infarction, brain edema and others. EFFECT: new compounds, valuable medicinal properties. 95 cl, 2 dwg, 51 tbl, 656 ex