FIELD: chemistry.
SUBSTANCE: method implies carbonylation of compound of formula 
, where each of R12, R13 and R14 stands for eliminated group, in solvent, in the presence of organoaluminium reagent (preferably, dimethylaluminium chloride) and palladium catalyst (preferably, tetrakis(triphenylphosphine)palladium) in carbon oxide atmosphere, to obtain compounds of formula 
, where R12 and R13 stand for above protective groups, and R15 stands for СН3, С2Н5, С3Н7 or С4Н9.
EFFECT: improved carbonylation method for preparation of intermediates in synthesis of new vitamin D derivatives.
2 cl, 6 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF VITAMIN D, COMPOUNDS PHARMACEUTICAL COMPOSITION, THERAPEUTIC AGENT, TREATMENT METHOD | 2001 |
|
RU2230738C9 |
| 22-THIAVITAMIN D DERIVATIVES, METHOD OF PREPARATION THEREOF, METHOD FOR PREPARATION OF COMPOUNDS, AND COMPOUNDS | 1995 |
|
RU2142941C1 |
| DERIVATIVE OF VITAMIN D AMIDE AND PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2139276C1 |
| STEREOSELECTIVE SYNTHESIS OF VITAMINE D ANALOGUES | 2005 |
|
RU2380359C2 |
| 9,10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL AGENTS | 2007 |
|
RU2440980C2 |
| ANALOGUES OF VITAMIN D, COMPOSITIONS CONTAINING INDICATED ANALOGUES AND THEIR USING | 2003 |
|
RU2320644C2 |
| ANALOGS OF VITAMIN D, METHOD OF THEIR SYNTHESIS, DIASTEREO- -ISOMER, PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2163234C2 |
| ANALOGS OF VITAMIN D,, A METHOD OF THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2126385C1 |
| NOVEL METHOD FOR SYNTHESIS OF INTERMEDIATE COMPOUNDS, USED IN SYNTHESIS OF VITAMIN D ANALOGUES | 2005 |
|
RU2378252C2 |
| ANALOGS OF VITAMIN , METHODS OF THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION AND A METHOD OF TREATMENT | 1993 |
|
RU2128168C1 |
