FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to N-substituted hydroxyalkyl or carboxyalkylhydroxyalkyl analogs of 9- and/or 10-oxo-4H-benzo[4,5]-cyclohepta[1,2-b]thiophene compounds or their 9-OH- and/or 10-OH-substituted analogs of the formula (I) 
where R means hydroxy-C2-C6-alkyl, carboxy-C1-C6-alkoxy-C1-C6-alkyl that show antihistaminic and anti-asthmatic properties with decreased sedative adverse effects. Invention describes also their optically active isomers and pharmaceutically acceptable salts. Compounds exert prophylaxis effect on the enhanced reactivity of smooth muscles also. EFFECT: improved prophylaxis and treatment, valuable medicinal properties of compounds. 20 cl, 11 tbl, 15 ex
