FIELD: chemistry.
SUBSTANCE: there is disclosed improved method of producing connection of formula [II] 
, being intermediate in fluticasone propionate synthesis by etherification of C-17 hydroxyl group 6α,9α-difluoro-11β, 17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-thiocarboxylic acid, compound of formula [I] . Method involves processing of compound [I] with small excess of carboxylic acid chloranhydride of general formula R-COCl where R stands for -CH2CH3, -CH2CH2CH3 or -CH(CH3)2, in inert solvent, with tertiary amine added. Preferentially, method is enabled with using pyridine with acetone added at temperature 5°C to -20°C.
EFFECT: method enables to eliminate intermediate byproduct.
13 cl, 3 ex
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