CYANOGUANIDINES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL PREPARATION BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel cyanoguanidines of the formula (I): or their tautomeric forms where addition to pyridine ring is carried out at 3 or 4 position; R₁ means one or more substitutes that can be similar or different and taken among group consisting of hydrogen, halogen atom or C₁-C₄-alkoxy-group; X means linear or branched, saturated or unsaturated C₉-C₂₀-hydrocarbon radical or group Q-Ar-R where Ar means phenyl; Q means linear or branched, saturated or unsaturated C₅-C₂₀-bivalent hydrocarbon radical; R means hydrogen or halogen atom. Compounds of the formula (I) inhibit unfavorable cells proliferation and can be used in medicine. EFFECT: improved methods of synthesis, valuable medicinal properties of compounds. 8 cl, 3 tbl, 26 ex