CYANOGUANIDINES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL PREPARATION BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel cyanoguanidines of the formula (I): where addition to pyridine ring is carried out at 3 or 4 position; R₁ means one or more substitutes taken among group consisting of hydrogen atom, C₁-C₄-alkyl or alkoxy-group; Q means C₄-C₂₀-linear saturated bivalent hydrocarbon radical; X means carbonyl, carbonylamino-group, aminocarbonyl, oxycarbonylhydroxy-group, oxycarbonyl, carbonylhydroxy-group, aminocarbonylhydroxy-group, aminothiocarbonylhydroxy-group, oxycarbonylamino-group or oxythiocarbonylamino-group; Y means phenylene; R₂ means hydrogen, halogen atom. Compounds of the formula (I) show inhibitory activity against unfavorable cells proliferation and can be used in medicine. EFFECT: improved methods of synthesis, valuable medicinal properties of compounds. 9 cl, 2 tbl, 15 ex