PYRIDINECARBOXAMIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

Abstract RU 2200157 C2

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel pyridinecarboxamidines of the formula (I) or their tautomeric forms where addition to pyridine is carried out at position 2, 3 or 4; R₁ means hydrogen atom; Q means C₁-C₉-bivalent saturated hydrocarbon radical; X means methylene group or oxygen atom; R means hydrogen, halogen atom, nitro-group, methylene-dioxy-group, alkyl or alkoxy-group containing from 1 to 4 carbon atoms, or their pharmaceutically acceptable nontoxic salts and N-oxides. Compounds of the formula (I) inhibit undesirable cell proliferation, for example, skin cells and cancer cells and can be used in medicine. EFFECT: improved method of synthesis, valuable medicinal properties of compounds. 6 cl, 3 tbl, 19 ex

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RU 2 200 157 C2

Authors

Ottosen Ehrik Rjutter

Dates

2003-03-10—Published

1998-05-15—Filed