FIELD: biology, medicine, immunology. SUBSTANCE: invention relates to the use of therapeutic compounds in modification of interactions of T-cells, antigen-presenting cells with T-cells and interactions between pathogenic organisms and immunocompetent host-cells. In part, invention relates to the use of these compounds in modification of interactions between proteins Notch and their ligands and to the use of such compounds in production of medicinal agents used for treatment of states, for example, transplant rejection, autoimmune processes, allergy and asthma and infectious diseases. The advantage of invention involves the development of agent inhibiting T-cellular interactions resulting to infectious tolerance and that can be used in production of medicinal preparations for immunotherapy carrying out. EFFECT: valuable biological and medicinal properties of ligands. 12 cl, 9 dwg, 2 tbl, 12 ex
