DERIVATIVES OF AZETHIDINE AND PYRROLIDINE Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of azethidine and pyrrolidine of the general formula: where A means optionally unsaturated 5- or 6-membered ring that can comprise heteroatom taken among N and S and can be substituted with oxo- or (1-6C)-alkyl; R¹,R²,R³ mean independently each of other H, (1-6C)-alkyl, (1-6C)-alkoxy- group, (1-6C)-alkoxy-(1-6C)-alkyl, halogen atom; X means O or S atom; n = 1 or 2; or its pharmaceutically acceptable salt but with exception of 3-(naphtha-1-yl-oxy)-pyrrolidine and 3-(5,6,7,8-tetrahydro-naphth-1-yl- oxy)-pyrrolidine. Compounds of the formula (I) exhibit affinity to receptor 5-HT_2c that allows to use their in pharmaceutical composition for treatment or prophylaxis of serotonin-dependent disorders. EFFECT: valuable medicinal properties of compounds. 7 cl, 2 tbl, 12 ex