COMPOSITION FOR GLOMERULOPATHY TREATMENT AND PROPHYLAXIS, NOVEL COMPOUNDS COMPRISING TO THEREOF, PHARMACEUTICAL COMPOSITION FOR INHIBITION OF MATRIX METALLOPROTEINASES ACTIVITY AND COMPOSITION FOR INHIBITION OF COLLAGENASES OF TYPE IV Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, biochemistry, pharmacy. SUBSTANCE: invention describes composition used for treatment and prophylaxis of glomerulopathy that comprises compound of the formula (I) where R¹ means hydrogen atom, (lower) alkyl, optionally substituted -CONHPh or (lower) alkylthio-group, phenyl, optionally substituted hydroxy-group, phenyl-(lower)-alkyl or indole-3-yl-(lower)-alkyl, optionally substituted (lower) alkoxy-group; R² means hydrogen atom or (lower) alkyl; R³ means 1,4-phenylene or 2,5-thiophenediyl; R⁴ means a substituent represented by structural fragments (a) , (b) , (c) , (d) , (e) , (f) , (g) , (j) , (k) or (l) where R⁵ means hydrogen atom, hydroxy-group, (lower) alkoxy-group, optionally substituted dialkylamino-group, (lower) alkylthio-group, halogen atom, (lower) halide alkyl, amino-group optionally substituted with (lower) alkyl, (lower) alkyl optionally substituted with azido-group or hydroxy-group, nitro-group, cyano-group, acyl group, -CONH₂, -NHCOR^D where R^D means (lower)-alkyl, morpholino-group; R⁶ means phenyl, (lower) alkyl optionally substituted with hydroxy-group, (lower) alkyloxy-group, (lower) alkylthio-group, amino-group optionally substituted with (lower) alkyl, morpholino-group or 1-pyrrolidinyl and Y means NHOH or OH, its optically active isomer, pharmaceutically acceptable salt or hydrate. Invention describes also: novel compounds of formulas: (XVII) , (XVIII) , (XIX) , (XX) , (XXII) and (XXIII) where R¹ has values indicated above and values R¹⁴ and R¹⁰ fall within values R⁵ and R², respectively, and pharmaceutical composition used for inhibition of matrix metalloproteinases activity and composition for inhibition of activity of collagenases of type IV. EFFECT: valuable medicinal and biochemical properties of compounds and composition. 37 cl, 13 tbl, 5 dwg, 121 ex