NUCLEIC ACID SEQUENCE ENCODING HIV-1 GAG PROTEIN, METHOD FOR ITS PREPARING, VECTOR CONTAINING THEREOF, PROTEIN ENCODED BY ITS, PHARMACEUTICAL COMPOSITION AND THEIR USING IN PROPHYLAXIS AND/OR TREATMENT OF HIV-INFECTION AND AIDS Russian patent published in 2007 - IPC C12N15/48 C12N15/63 C07K14/16 A61K39/21 

FIELD: medicine, virology, molecular biology, genetic engineering.

SUBSTANCE: invention relates to nucleic acid constructions and to vaccine preparations containing such construction and to using such preparations in medicine. Nucleotide sequence that encodes HIV-1 gag protein or its fragment containing gag epitope and HIV-1 Nef protein or its fragment containing nef epitope, and RT protein or its fragment containing RT epitope is coupled operatively with heterologous promoter wherein gag sequence is optimized by cordons. This sequence is a component of pharmaceutical composition and used in treatment and/or prophylaxis of HIV-infection and AIDS.

EFFECT: valuable medicinal properties of constructions, protein and pharmaceutical composition.

15 cl, 50 dwg, 22 ex